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"Once Human: Top PvE & PvP Builds - Weapons, Gear"

Author : Gabriella Update : May 06,2025

In Once Human, the strength of your gear and weapon choices directly impacts your performance in battle. Whether you're facing off against corrupted beasts in PvE zones or launching raids on player settlements in PvP, a well-synergized build can mean the difference between victory and defeat.

This guide delves into four of the most potent builds available in the latest version of Once Human, providing in-depth details on weapons, gear modifications, synergy effects, and playstyle tips. From builds designed for area of effect (AoE) damage to those focused on damage over time (DoT) and critical burst damage, each setup has been rigorously tested for both solo and team play scenarios.

If you're new to Once Human, be sure to check out our Beginner’s Guide for a thorough introduction to the game!

Once Human Build Guide

Final Tips for Optimizing Your Build

  • Sync weapon effects and mods: Select gear that amplifies your weapon’s elemental or status effects for maximum impact.
  • Keep upgrading: The rarity and enhancement level of your gear significantly increase its effectiveness. Always strive to keep your equipment up-to-date.
  • Craft backup loadouts: A secondary build based on different elements can be crucial for adapting to various mutant types or countering PvP strategies.

Each build in Once Human is tailored for specific scenarios, whether it's tackling boss fights, clearing waves of enemies, or executing swift PvP takedowns. Experiment with different loadouts, fine-tune your gear mods, and be ready to switch builds based on the mission type or the resistance of your enemies.

For an optimal gaming experience—featuring lag-free aiming, efficient multi-instance farming, and quick inventory management—consider playing Once Human on BlueStacks. Enjoy full control support and ultra-smooth frame rates to enhance your gameplay to the fullest.